On March 17, 2026, the Department of Energy (“DOE”) issued a Request for Application (“RFA”) under the Genesis Mission, a White House-led AI initiative announced in November 2025. The RFA, with $293.76 million in anticipated total funding, solicits project proposals for 21 areas ranging from advanced manufacturing and industrial productivity to energy and nuclear physics. Applications for Phase I and letters of intent for Phase II are both due April 28, 2026. This blog post reviews the development of the Genesis Mission since last year and summarizes the key elements of the current funding opportunity.
